Altered Cardiac Innervation Predisposes to Ventricular Arrhythmia
نویسندگان
چکیده
منابع مشابه
Absence of the inhibitory G-protein Galphai2 predisposes to ventricular cardiac arrhythmia.
BACKGROUND We explored the role that inhibitory heterotrimeric G-proteins play in ventricular arrhythmia. METHODS AND RESULTS Mice with global genetic deletion of Galpha(i2) [Galpha(i2) (-/-)] were studied and found, based on telemetry, to have a prolonged QT interval on surface ECG when awake. In vivo electrophysiology studies revealed that the Galpha(i2) (-/-) mice have a reduced ventricula...
متن کاملAbsence of the inhibitory G - protein , G i 2 , predisposes to ventricular cardiac arrhythmia
tributed equally to this study. Abstract Background-We have explored the role that inhibitory heterotrimeric G-proteins have in
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2014
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2013.08.1629